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  • Title: Copper-catalyzed ring expansion of 2-aminobenzothiazoles with alkynyl carboxylic acids to 1,4-benzothiazines.
    Author: Qiu JW, Hu BL, Zhang XG, Tang RY, Zhong P, Li JH.
    Journal: Org Biomol Chem; 2015 Mar 14; 13(10):3122-7. PubMed ID: 25632941.
    Abstract:
    A new ring expansion of 2-aminobenzothiazoles with alkynyl carboxylic acids was developed, which allows for one-pot synthesis of 1,4-benzothiazines in moderate to excellent yields. The cascade reaction was achieved through decarboxylative coupling, nucleophilic ring-opening reaction and intramolecular hydroamination process.
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