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  • Title: An organocatalytic Michael-cyclization cascade of 4-oxa-α,β-unsaturated carboxylic acids with aldehydes: facile synthesis of chiral γ-lactols and trisubstituted γ-lactones.
    Author: Lin JB, Xu SM, Xie JK, Li HY, Xu PF.
    Journal: Chem Commun (Camb); 2015 Feb 28; 51(17):3596-9. PubMed ID: 25633800.
    Abstract:
    An organocatalytic Michael-cyclization cascade of aldehydes with 4-oxa-α,β-unsaturated carboxylic acids has been developed, giving functionalized γ-lactols with high yields and enantioselectivities. The products could be easily transformed into complex trisubstituted γ-lactones and γ-lactams.
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