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Title: Absolute configuration of labdane diterpenoids from Physalis nicandroides. Author: Maldonado E, Pérez-Castorena AL, Romero Y, Martínez M. Journal: J Nat Prod; 2015 Feb 27; 78(2):202-7. PubMed ID: 25634541. Abstract: A mixture of the new epimeric labdenetriols 1 and 2 was isolated from the aerial parts of Physalis nicandroides. The structures of 1 and 2, including their absolute configurations, were established by analyses of their spectroscopic data, together with the X-ray diffraction analysis of acetonide 3 and chemical correlation with (-)-(13E)-labd-13-ene-8α,15-diol (6), whose absolute configuration was also confirmed by X-ray analysis of its dibromo derivative 7. The epimeric labdenediols 8 and 9, the known labdanes 6 and 11, and the acylsucroses 12 and 13 were also isolated. Labdanes 6 and 11 showed moderate anti-inflammatory activities in the induced ear edema model.[Abstract] [Full Text] [Related] [New Search]