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  • Title: Radioimmunoimaging for diagnosis of bone marrow involvement in breast cancer and malignant lymphoma.
    Author: Reske SN, Karstens JH, Gloeckner W, Steinsträsser A, Schwarz A, Ammon J, Buell U.
    Journal: Lancet; 1989 Feb 11; 1(8633):299-301. PubMed ID: 2563458.
    Abstract:
    Granulopoietic bone-marrow was scintigraphically imaged in 15 patients with carcinoma of the breast and known skeletal metastases, 10 patients with malignant lymphomas, and 15 controls without suspected malignant disease, with a technetium-99m labelled murine monoclonal IgG1 antibody directed against nonspecific cross-reacting antigen (NCA-95) and carcinoembryonic antigen. Immunoscintigraphy revealed more lesions than did bone scanning in both patient groups. This method offers a sensitive, cost-effective, and easy-to-perform whole body technique for evaluating metastatic spread.
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