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  • Title: Risk Factors and Prognosis for Myoepithelial Carcinoma of the Major Salivary Glands.
    Author: Su YX, Roberts DB, Hanna EY, El-Naggar A, Saylam G, Frank SJ, Weber RS, Kupferman ME.
    Journal: Ann Surg Oncol; 2015 Oct; 22(11):3701-7. PubMed ID: 25636455.
    Abstract:
    BACKGROUND: The clinical behavior and treatment outcomes of salivary gland myoepithelial carcinoma have yet to be clearly defined. The current study investigated risk factors and prognoses for this tumor. METHODS: A retrospective review of the medical records for 32 patients with myoepithelial carcinoma of the major salivary glands was performed. Their clinical parameters were assessed to identify correlations with local-regional recurrence, distant metastasis, and survival. RESULTS: The 5-year survival rate was 71 %. Of the reviewed patients, 41 % had local-regional recurrences, and 22 % had distant metastases. Age of 60 years or younger was a predictive factor for distant metastasis. Patients with neck lymph nodes clinically positive for carcinoma had shorter overall survival durations than those with nodes negative for carcinoma. CONCLUSIONS: Myoepithelial carcinoma of the major salivary glands is characterized by a high incidence of local-regional recurrence and distant metastasis. Adjuvant therapy is indicated for selected patients with high-risk disease.
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