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  • Title: The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn.
    Author: Fatmawati S, Ersam T, Shimizu K.
    Journal: Phytomedicine; 2015 Jan 15; 22(1):49-51. PubMed ID: 25636870.
    Abstract:
    We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 µg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 µM.
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