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  • Title: A novel respiratory gating method for oncologic positron emission tomography based on bioimpedance approach.
    Author: Koivumäki T, Teuho J, Teräs M, Vauhkonen M, Hakulinen MA.
    Journal: Ann Nucl Med; 2015 May; 29(4):351-8. PubMed ID: 25638030.
    Abstract:
    OBJECTIVE: Respiratory motion causes loss of image quality and inaccuracy of quantification in oncologic positron emission tomography (PET) imaging. This study introduces a bioimpedance-based gating method for compensation of respiratory motion artefacts. METHODS: The bioimpedance-based respiratory gating method was studied parallel to a clinically used respiratory gating method [Real-time Position Management by Varian Medical Systems] in 4D PET/CT acquisition of 9 oncologic patients. The quantitative analysis consisted of the evaluation of tumour SUVpeak, SUVmax and volume. Additionally, target-to-background ratios as well as motion in cranial-caudal and anterior-posterior directions were measured. The evaluation was performed with amplitude- and time-based gating using averaged attenuation correction maps. RESULTS: Bioimpedance gating resulted in 17.7-18.9 % increase in mean SUVpeak and 20.0-21.4 % decrease in mean volume compared to non-gated images. The maximum motion measured from the bioimpedance-gated images was 19 mm in cranial-caudal direction and 9 mm in anterior-posterior direction. CONCLUSIONS: Bioimpedance-based respiratory gating compensates the adverse effects of motion in oncologic PET imaging.
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