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  • Title: Design and synthesis of novel 1,2,3-triazole-pyrimidine-urea hybrids as potential anticancer agents.
    Author: Ma LY, Wang B, Pang LP, Zhang M, Wang SQ, Zheng YC, Shao KP, Xue DQ, Liu HM.
    Journal: Bioorg Med Chem Lett; 2015 Mar 01; 25(5):1124-8. PubMed ID: 25655718.
    Abstract:
    A series of novel 1,2,3-triazole-pyrimidine-urea hybrids were designed, synthesized and evaluated for anticancer activity against four selected cancer cell lines (MGC-803, EC-109, MCF-7 and B16-F10). Majority of the synthesized compounds exhibited moderate to potent activity against all the cancer cell lines assayed. Particularly, compounds 26, 30 and 38 exhibited excellent growth inhibition against B16-F10 with IC50 values of 32nM, 35nM and 42nM, respectively. Flow cytometry analysis demonstrated that compound 26 induced the cellular apoptosis in a concentration-dependent manner.
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