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  • Title: Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32.
    Author: Popescu NC, King CR, Kraus MH.
    Journal: Genomics; 1989 Apr; 4(3):362-6. PubMed ID: 2565881.
    Abstract:
    Through the use of a cDNA probe, the human erbB-2 gene was localized by in situ hybridization of normal human chromosomes at 17q11-q21. In situ hybridization of chromosomes derived from fibroblasts carrying a constitutional 15;17t(q22.3;q11.21) translocation showed that the erbB-2 gene was relocated on the rearranged chromosome 15. These results as well as grain localization on prophase chromosomes locate the erbB-2 gene at 17q12-q21.32. This localization may facilitate the search for human malignancies with chromosome changes involving the erbB-2 gene.
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