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  • Title: Increased serum sclerostin in postoperative biliary atresia.
    Author: Honsawek S, Udomsinprasert W, Chaiwatanarat T, Vejchapipat P, Chongsrisawat V, Poovorawan Y.
    Journal: Clin Chim Acta; 2015 Mar 10; 442():136-40. PubMed ID: 25659290.
    Abstract:
    BACKGROUND: We determined the relationship between serum sclerostin and disease severity of biliary atresia (BA). METHODS: Seventy postoperative BA patients and 35 controls were recruited. Serum sclerostin, C-terminal telopeptide of type I collagen (CTX), and osteocalcin were analyzed using ELISA. Bone mineral density (BMD) of the lumbar spine was measured by dual energy X-ray absorptiometry. RESULTS: BA patients had significantly higher serum sclerostin than controls. Serum sclerostin was markedly elevated in jaundice patients compared with jaundice-free patients. Serum osteocalcin was not different, whereas serum CTX was greater in BA patients than controls. BMD of jaundice patients was significantly lower than jaundice-free patients. Additionally, serum sclerostin was correlated with biochemical parameters and BMD in BA. CONCLUSION: Increased sclerostin levels were associated with liver dysfunction and the severity of BA, suggesting that sclerostin may reflect the deterioration of hepatic function and the outcome in postoperative BA.
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