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  • Title: [Treatment of tubal ectopic pregnancy by methotrexate].
    Author: Lesavre M, Curinier S, Capmas P, Rabischong B, Fernandez H.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 2015 Mar; 44(3):212-9. PubMed ID: 25661494.
    Abstract:
    OBJECTIVES: To make a literature analyse about methotrexate as a treatment of tubal ectopic pregnancy. MATERIALS AND METHODS: We made a PubMed research and found articles, randomized control studies, systematic revues and meta-analyses of the Cochrane Database about ectopic pregnancies treated by methotrexate. We made a summary of these articles. RESULTS: Methotrexate can be used as a treatment of tubal ectopic pregnancy with hCG<5000 UI/L and expectative is an option if hCG level is lower than 1500 UI/L. Medical treatment by methotrexate seems to be less effective than surgical salpingotomy but the rate of recurrence and the rate of intra-uterine pregnancy are similar regardless of the treatment chosen. Fertility seems to be the same after treatment by methotrexate. Economically, methotrexate is less expensive than the surgical management (laparoscopy). CONCLUSION: Methotrexate can be used as a treatment of tubal ectopic pregnancies if every criterions of safety are gathered.
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