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  • Title: Persistent hypotensive effect of L-dopa given early during development to rats with inherited stress-induced arterial hypertension.
    Author: Naumenko EV, Maslova LN, Gordienko NI, Amstyslavski SY, Dygalo NN, Markel AL.
    Journal: Brain Res Dev Brain Res; 1989 Apr 01; 46(2):205-12. PubMed ID: 2566397.
    Abstract:
    A long-lasting decrease of the basal and stress-induced arterial blood pressure was obtained in rats with inherited emotional stress-induced arterial hypertension by means of injections of the dopamine precursor L-DOPA during early development (21-25 days after birth). The restoring effect of L-DOPA was produced through enhancement of synthesis of the brain noradrenaline and, perhaps, adrenaline. The effect was associated with a normalization of the response of the brain adrenergic system to noradrenaline and, presumably, with increase of tyrosine hydroxylase activity in the cortex and hindbrain.
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