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  • Title: First report of macrolide resistance gene erm(T) harbored by a novel small plasmid from Erysipelothrix rhusiopathiae.
    Author: Xu CW, Zhang AY, Yang CM, Pan Y, Guan ZB, Lei CW, Peng LY, Li QZ, Wang HN.
    Journal: Antimicrob Agents Chemother; 2015 Apr; 59(4):2462-5. PubMed ID: 25666150.
    Abstract:
    The macrolide resistance gene erm(T) was identified for the first time in a porcine Erysipelothrix rhusiopathiae isolate from swine in China. The novel 3,749-bp small plasmid pER29, which carries erm(T), had a G+C content of 31% and four distinct open reading frames. The presence of pER29 increased by at least 128-fold the MICs of clindamycin and erythromycin for E. rhusiopathiae. The fitness cost of pER29 could be responsible for the low frequency of erm(T) in E. rhusiopathiae.
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