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  • Title: Developmental exposure to bisphenol A alters the differentiation and functional response of the adult rat uterus to estrogen treatment.
    Author: Vigezzi L, Bosquiazzo VL, Kass L, Ramos JG, Muñoz-de-Toro M, Luque EH.
    Journal: Reprod Toxicol; 2015 Apr; 52():83-92. PubMed ID: 25666754.
    Abstract:
    We assessed the long-term effect of perinatal exposure to bisphenol A (BPA) on the rat uterus and the uterine response to estrogen (E2) replacement therapy. BPA (0.5 or 50μg/kg/day) was administered in the drinking water from gestational day 9 until weaning. We studied the uterus of female offspring on postnatal day (PND) 90 and 360, and the uterine E2 response on PND460 (PND460-E2). On PND90, BPA-exposed rats showed altered glandular proliferation and α-actin expression. On PND360, BPA exposure increased the incidence of abnormalities in the luminal and glandular epithelium. On PND460-E2, the multiplicity of glands with squamous metaplasia increased in BPA50 while the incidence of glands with daughter glands increased in BPA0.5. The expression of steroid receptors, p63 and IGF-I was modified in BPA-exposed rats on PND460-E2. The long-lasting effects of perinatal exposure to BPA included induction of abnormalities in uterine tissue and altered response to E2 replacement therapy.
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