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  • Title: Neural reconstruction methods of restoring bladder function.
    Author: Gomez-Amaya SM, Barbe MF, de Groat WC, Brown JM, Tuite GF, Corcos J, Fecho SB, Braverman AS, Ruggieri MR.
    Journal: Nat Rev Urol; 2015 Feb; 12(2):100-18. PubMed ID: 25666987.
    Abstract:
    During the past century, diverse studies have focused on the development of surgical strategies to restore function of a decentralized bladder after spinal cord or spinal root injury via repair of the original roots or by transferring new axonal sources. The techniques included end-to-end sacral root repairs, transfer of roots from other spinal segments to sacral roots, transfer of intercostal nerves to sacral roots, transfer of various somatic nerves to the pelvic or pudendal nerve, direct reinnervation of the detrusor muscle, or creation of an artificial reflex pathway between the skin and the bladder via the central nervous system. All of these surgical techniques have demonstrated specific strengths and limitations. The findings made to date already indicate appropriate patient populations for each procedure, but a comprehensive assessment of the effectiveness of each technique to restore urinary function after bladder decentralization is required to guide future research and potential clinical application.
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