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  • Title: Comparison of the effects of dezocine, fentanyl, and placebo on emergence agitation after sevoflurane anesthesia in children.
    Author: Li X, Xia Q, Li W.
    Journal: Int J Clin Pharmacol Ther; 2015 Mar; 53(3):241-6. PubMed ID: 25669611.
    Abstract:
    OBJECTIVES: The purpose of the study was to compare the efficacy and adverse events of dezocine with that of fentanyl or placebo for the control of emergence agitation. METHODS: 114 children scheduled for adenotonsillectomy under sevoflurane anesthesia were allocated randomly into 1 of the 3 groups to receive dezocine 0.1 mgxkg(-1) (group D, n=38), fentanyl 1 μg×kg(-1) (group F, n=38), or saline (group S, n=38) just before the end of anesthesia. Emergence agitation scores were assessed. Postoperative pain scores, awakening and extubation times, and the incidence of adverse effects were recorded. RESULTS: Emergence agitation scores, the incidence of emergence agitation and severe emergence agitation were significantly lower in groups D and F than in group S (p=0.021, p=0.018, and p=0.028, respectively). The postoperative pain scores were lower in groups D and F as compared to group S (p=0.01). Awakening and extubation times in groups D and F were longer than that of group S (p=0.001 and p=0.000, respectively). The overall incidence of postoperative complications was higher in group F compared to that in groups D and S (p=0.01). CONCLUSIONS: In children undergoing adenotonsillectomy under sevoflurane anesthesia, a single IV injection of dezocine 0.1 mgxkg(-1) and fentanyl 1 μg×kg(-1) were comparable in decreasing the incidence and severity of emergence agitation. However, the use of dezocine was associated with a lower incidence of postoperative side effects.
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