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  • Title: New evidence that L-glutamate is a transmitter at the squid giant synapse.
    Author: De Santis A, Messenger JB.
    Journal: Q J Exp Physiol; 1989 Mar; 74(2):219-22. PubMed ID: 2567041.
    Abstract:
    Experiments are described showing unequivocally that transmission at the squid giant synapse can be reversibly blocked by L-glutamate and its agonists kainate, quisqualate and AMPA, though not by NMDA. This effect is presumably brought about by desensitization. The glutamate antagonists cis-2,3-PDA, GAMS and the new quinoxalinediones CNQX and DNQX are also potent reversible blockers. These findings provide new evidence that L-glutamate is a transmitter at the giant synapse and further suggest that the glutamate receptor may be of the non-NMDA type.
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