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  • Title: Close linkage of MEN2A with RBP3 locus in Japanese kindreds.
    Author: Yamamoto M, Takai S, Miki T, Motomura K, Okazaki M, Nishisho I, Tateishi H, Miyauchi A, Honjo T, Pakstis AJ.
    Journal: Hum Genet; 1989 Jun; 82(3):287-8. PubMed ID: 2567278.
    Abstract:
    The gene responsible for multiple endocrine neoplasia type 2A (MEN2A) has recently been assigned to the pericentromeric region of chromosome 10 in European Caucasian kindreds by linkage analysis using a DNA marker, interstitial retinol-binding protein 3 (RBP3). We have found tight linkage between the MEN2A and RBP3 loci in Japanese MEN2A kindreds. The maximum lod score is 5.19 at a recombination fraction of 0.00. This result suggests that mutation of a certain gene close to RBP3 is responsible for MEN2A irrespective of ethnic backgrounds.
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