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  • Title: Optimization of phase-contrast MRI for the quantification of whole-brain cerebral blood flow.
    Author: Peng SL, Su P, Wang FN, Cao Y, Zhang R, Lu H, Liu P.
    Journal: J Magn Reson Imaging; 2015 Oct; 42(4):1126-33. PubMed ID: 25676350.
    Abstract:
    BACKGROUND: Whole-brain cerebral blood flow (CBF) measured by phase-contrast MRI (PC-MRI) provides an important index for brain function. This work aimed to optimize the PC-MRI imaging protocol for accurate CBF measurements. METHODS: Two studies were performed on a 3 Tesla system. In Study 1 (N = 12), we optimized in-plane resolution of PC-MRI acquisition for CBF quantification by considering accuracy, precision, and scan duration. In Study 2 (N = 7), we assessed the detrimental effect of nonperpendicular imaging slice orientation on CBF quantification. Both One-way analysis of variance with repeated measurement and Friedman test were used to examine the effects of resolution and angulation on CBF quantification. Additionally, we evaluated the inter-rater reliability in PC-MRI data processing. RESULTS: Our results showed that CBF measurement with 0.7 mm resolution could be overestimated by up to 13.3% when compared with 0.4 mm resolution. Moreover, CBF could also be overestimated by up to 18.8% when the slice orientation is deviated by 30° from the ideal angulation. However, within 10° of the ideal slice orientation, estimated CBF was not significantly different from each other (P = 0.23 and 0.45 for internal carotid artery and vertebral artery, respectively). Inter-rater difference was <3%. CONCLUSION: For fast and accurate quantification of whole-brain CBF with PC-MRI, we recommend the use of an imaging resolution of 0.5 mm and a slice orientation that is less than 10° from vessel's axial plane.
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