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  • Title: OASL-a new player in controlling antiviral innate immunity.
    Author: Zhu J, Ghosh A, Sarkar SN.
    Journal: Curr Opin Virol; 2015 Jun; 12():15-9. PubMed ID: 25676874.
    Abstract:
    The cellular innate immune system plays a crucial role in mounting the initial resistance to virus infection. It is comprised of various pattern-recognition receptors that induce type I interferon production, which further shapes the adaptive immunity. However, to overcome this resistance and promote replication, viruses have evolved mechanisms to evade this host innate immune response. Here we discuss a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like (OASL) protein, which can potentially be used to overcome viral evasion and enhance innate immunity.
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