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  • Title: [The cyclic nucleotide system in various sections of the dog myocardium in experimental infarction].
    Author: Frolova NIu, Printsev MD, Tret'iakov AV, Kozhetiakin LA, Korovkin BF.
    Journal: Vopr Med Khim; 1989; 35(1):64-8. PubMed ID: 2568032.
    Abstract:
    Distinct increase and then decrease in content of cyclic nucleotides was observed in dog myocardium ventricles and auricles within early periods of heart infarction (10 min-4 hrs). Within a day after ligation of artery the ratio cAMP/cGMP was considerably decreased as a result of activation of guanylate cyclase and cAMP-phosphodiesterase as well as due to a decrease in activity of adenylate cyclase. Acute ischemia of small area of the heart left ventricle caused impairment of cyclic nucleotide metabolism in all the heart muscle.
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