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  • Title: [Effect of beta-adrenergic blockaders and nitrates on left ventricular diastolic function in patients with ischemic heart disease].
    Author: Ivanov I.
    Journal: Vutr Boles; 1989; 28(1):26-31. PubMed ID: 2568033.
    Abstract:
    By means of M-type electrocardiography the anapriline (propranolol--40 mg) and nitrosorbide (isosorbide dinitrate--10 mg) action on the left ventricular diastolic function was studied in the conditions of acute experiment in 55 patients with stable stenocardia. It was established that anapriline lengthens the diastole (at the expense of diastasis), decreases the myocardial relaxation speed and the fast filling and causes an increase of the telediastolic volume. Nitrosorbide decreases the filling velocity in the three diastolic phases without changing its duration and leads to a decrease of the telediastolic volume. In the combination of the two drugs anaprilin acts mainly on the duration, volume and speed indices of the left ventricular diastolic function while nitrosorbide acts mainly on the venous flow towards the heart and reduces the unfavourable action of anapriline on myocardial relaxation.
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