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  • Title: Improved screening method for beta-blockers in urine using solid-phase extraction and capillary gas chromatography-mass spectrometry.
    Author: Leloux MS, de Jong EG, Maes RA.
    Journal: J Chromatogr; 1989 Mar 24; 488(2):357-67. PubMed ID: 2568364.
    Abstract:
    An improved screening method for beta-blockers in urine is proposed, involving enzymatic hydrolysis, solid-phase extraction and capillary gas chromatography-mass spectrometry. Several extraction methods for beta-blockers, such as conventional liquid-liquid and solid-phase extraction procedures, have been evaluated for at least eight beta-blockers. Additionally, the gas chromatographic properties and mass fragmentation of the trimethylsilyl-trifluoroacetyl, trifluoroacetyl and cyclic n-butylboronate derivatives of beta-blockers have been compared and evaluated with respect to their efficiency for screening urine. The resulting screening method proved to be a specific and sensitive procedure, enabling these analytes to be detected and identified up to 48 h after the administration of a dosage, usually encountered in doping cases.
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