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  • Title: New pregnane glycosides from Gymnema sylvestre.
    Author: Xu R, Yang Y, Zhang Y, Ren F, Xu J, Yu N, Zhao Y.
    Journal: Molecules; 2015 Feb 12; 20(2):3050-66. PubMed ID: 25685911.
    Abstract:
    Four new pregnane glycosides 1-4 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A-D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 1-4 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity.
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