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  • Title: Plasma level and renal excretion of iotrolan after lumbar injection in patients.
    Author: Weinmann HJ, Vogelsang H, Mützel W, Speck U.
    Journal: Fortschr Geb Rontgenstrahlen Nuklearmed Erganzungsbd; 1989; 128():224-7. PubMed ID: 2568801.
    Abstract:
    Ten milliliters of iotrolan containing 240 mg I/ml were injected into the lower lumbar subarachnoid space of ten patients. Plasma level and urinary and fecal excretion were monitored for 3 days after injection. The mean iodine concentration in the plasma of about 50 micrograms/ml (6% of the dose given in the total plasma volume) peaked at 1 to 2 hours after injection. After reaching the maximum values, the iotrolan concentration in the plasma decreased with a half-life of about 4 hours (median value). About 90% of the injected dose was found in the urine and about 1% was detected in the feces.
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