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  • Title: Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist.
    Author: Maj J, Rogóz Z, Skuza G, Sowińska H.
    Journal: J Neural Transm Gen Sect; 1989; 78(1):1-8. PubMed ID: 2569028.
    Abstract:
    The effects of single or repeated doses of antidepressant drugs (imipramine, amitriptyline, citalopram, mianserin) on rat locomotor hyperactivity induced by quinpirole, a dopamine D-2 receptor agonist, was investigated. Single doses of antidepressants do not change the effect of quinpirole, but enhance it when they are administered repeatedly. This enhancement is inhibited by (+/-)-sulpiride, a dopamine D-2 receptor antagonist. The results obtained indicate that the enhancement of dopaminergically-stimulated hyperactivity induced by repeated doses of antidepressants is mediated by dopamine D-2 receptors.
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