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  • Title: High-performance liquid chromatographic determination of bromazepam in human plasma.
    Author: Boukhabza A, Lugnier AA, Kintz P, Tracqui A, Mangin P, Chaumont AJ.
    Journal: Analyst; 1989 May; 114(5):639-41. PubMed ID: 2569276.
    Abstract:
    An assay using high-performance liquid chromatography has been developed for the determination of bromazepam in plasma. After a single-step extraction from basified samples with dichloromethane, using decarboxyloflazepate as an internal standard, samples were analysed using a reversed-phase Nova Pak 5-microns column with a mobile phase of methanol - phosphate buffer (60 + 40) adjusted to pH 7.6. The drugs were detected at 239 nm and the limit of detection was found to be 3 micrograms l-1 for bromazepam. The method is simple, rapid and sensitive and permits bromazepam levels in clinical and pharmacokinetic studies to be monitored.
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