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  • Title: Correlation between RsaI restriction fragment length polymorphism and electrophoretic types of human placental alkaline phosphatase.
    Author: Beckman G, Beckman L, Lundgren E, Millán JL, Sikström C.
    Journal: Hum Hered; 1989; 39(1):41-5. PubMed ID: 2569440.
    Abstract:
    Restriction fragment length polymorphism (RFLP) of human alkaline phosphatases was studied in a population sample from northern Sweden using a placental alkaline phosphatase (PLAP) cDNA probe. After digestion of human genomic DNA with RsaI the Southern blots showed DNA fragments most probably derived from three genes: PLAP, germ cell alkaline phosphatase (PLAP-like) and intestinal alkaline phosphatase. In agreement with a previous study, a two-allele polymorphism was found in PLAP with bands at 1.6 kilobases (A1) and 1.8 kilobases (A2). The gene frequencies of A1 and A2 were 0.46 and 0.54, respectively. There was a significant correlation between the RsaI RFLPs and electrophoretic types of PLAP; RSAI A2 showed an association with the ALP2p allele of PLAP.
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