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  • Title: Effect of histamine H1-receptor antagonist on the regulation of carbohydrate and lipid metabolism in rat liver.
    Author: Koyama Y, Imoto M, Tanaka M, Fukuda Y, Miyazawa Y, Nakano I, Ozawa T.
    Journal: Biochem Int; 1989 Feb; 18(2):399-403. PubMed ID: 2569872.
    Abstract:
    In order to elucidate the role of histamine in the liver, we studied the effect of a histamine H1-receptor antagonist on the carbohydrate and lipid metabolism in the rat liver. The administration of the H1-receptor antagonist decreased significantly the contents of glycogen and malonyl-CoA in the liver. However, it did not affect the levels of serum glucose and free fatty acid. These results suggest that histamine may play a part in the regulation of metabolism of carbohydrates and lipids in the liver.
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