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  • Title: Comparison of a New Integral-Based Half-Band Method for CT Measurement of Peripheral Airways in COPD With a Conventional Full-Width Half-Maximum Method Using Both Phantom and Clinical CT Images.
    Author: Cho YH, Seo JB, Kim N, Lee HJ, Hwang HJ, Kim EY, Oh SY.
    Journal: J Comput Assist Tomogr; 2015; 39(3):428-36. PubMed ID: 25700223.
    Abstract:
    OBJECTIVES: To compare a new integral-based half-band method (IBHB) and a conventional full-width half-maximum (FWHM) method in measuring peripheral airway dimensions at airway phantoms and thin-section computed tomography of chronic obstructive pulmonary disease (COPD). METHODS: The IBHB was validated and compared using airway phantoms and 50 patients with COPD. Airway parameters (wall area percentage [WA%], mean lumen radius, and mean wall thickness) were measured at fourth to sixth generations of the right apical bronchus. Matched results from 2 methods were compared and correlated with forced expiratory volume (FEV) in 1 second (FEV1), FEV1 / forced vital capacity (FVC), and global initiative for chronic obstructive lung disease (GOLD) stage. Linear regression analysis was performed using airway dimensions and emphysema index. RESULTS: The IBHB generated more accurate measurements at phantom study. Measured airway parameters by both methods at thin-section computed tomography study were significantly different (all P < 0.05, paired t test). The IBHB method-measured WA% and wall thickness were significantly smaller. Mean WA% with IBHB also showed better correlation than that with FWHM (FEV1, r = -0.52 vs -0.28; FEV1 / FVC, r = -0.41 vs r = -0.20; GOLD, 0.52 vs 0.33, respectively). Linear regression analysis revealed fifth-generation WA% measured by IBHB was an independent variable, and addition to emphysema index increased predictability (FEV1, r = 0.63; FEV1 / FVC, r = 0.61; GOLD, r = 0.70). CONCLUSIONS: The new IBHB measured peripheral airway dimensions differently than FWHM and showed better correlations with functional parameters in COPD.
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