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  • Title: Efficacy of low-dose metoprolol in neuroleptic-induced akathisia.
    Author: Kim A, Adler L, Angrist B, Rotrosen J.
    Journal: J Clin Psychopharmacol; 1989 Aug; 9(4):294-6. PubMed ID: 2570088.
    Abstract:
    Recent studies have shown that the beta-blockers can be effective treatments for neuroleptic-induced akathisia. However, the relative contributions of beta-1 versus beta-2 blockade to the therapeutic effect of beta-blockers remains unclear. We treated nine patients who had neuroleptic-induced akathisia with low doses (25-100 mg/day) of the beta-blocker metoprolol. At these doses metoprolol causes selective blockade of beta-1 receptors. Seven patients improved after metoprolol; no further substantial changes were seen after subsequent treatment with propranolol. This finding suggests that neuroleptic-induced akathisia can be improved by selective beta-1 blockade.
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