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  • Title: Thy-1+ dendritic epidermal cells undergo mitosis in vivo.
    Author: Miyauchi S, Hashimoto K.
    Journal: J Invest Dermatol; 1989 Sep; 93(3):429-31. PubMed ID: 2570113.
    Abstract:
    Recently, morphologic evidence that epidermal Langerhans cells (ELC) undergo a mitotic cycle in normal mouse ear skin has been presented. In the present study, using immunohistochemical staining, we examined the mitotic activity of Thy-1-positive dendritic epidermal cells (Thy-1+DEC) in the normal murine epidermis. A small number of Thy-1+DEC showed round, cleaved, paired, and paired dendritic morphologies, which are identical to those occurring during ELC mitosis. We conclude that normal Thy-1+DEC undergo mitosis within the epidermis to maintain their population in the murine epidermis.
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