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  • Title: Monoclonal antibodies neutralizing human leukocyte acid- and thermolabile interferon alpha.
    Author: Kontsek P, Borecký L, Lackovic V, Kontseková E, Sujanová Z, Novák M.
    Journal: Acta Virol; 1989 May; 33(3):254-61. PubMed ID: 2570512.
    Abstract:
    Using a high titred human leukocyte IFN alpha preparation which contained both acid- and thermolabile (AL-IFN alpha) and acid- and thermostable IFN alpha species in 9:1 proportion for immunization of BALB/c mice, five hybridomas secreting monoclonal antibodies that reacted with AL-IFN alpha were obtained. In antiviral and antiproliferative tests on HL-60 cells, their products showed high degree of specificity for AL-IFN alpha. The results suggest that both the "normal" leukocyte AL-IFN alpha and the IFN alpha found in sera of autoimmune and other chronic patients might belong to the same subtype of IFN alpha.
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