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  • Title: Ischemic flow threshold for extracellular glutamate increase in cat cortex.
    Author: Shimada N, Graf R, Rosner G, Wakayama A, George CP, Heiss WD.
    Journal: J Cereb Blood Flow Metab; 1989 Oct; 9(5):603-6. PubMed ID: 2570784.
    Abstract:
    Extracellular glutamate (Glu), cerebral blood flow (CBF), and auditory-evoked potentials (AEPs) were measured concurrently using microdialysis and hydrogen clearance in the auditory cortex of anesthetized cats during global ischemia of various severities. A threshold-type relationship was observed between extracellular Glu and CBF: Glu increased at CBF levels below about 20 ml/100 g/min. The Glu increase was related to the impairment of AEPs. The results suggest that Glu neurotoxicity is an important factor for ischemic neuronal injury even in penumbra.
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