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  • Title: Effect of pyridoxamine on semicarbazide-sensitive amine oxidase activity of rabbit lung and heart.
    Author: Buffoni F, Banchelli G, Bertocci B, Raimondi L.
    Journal: J Pharm Pharmacol; 1989 Jul; 41(7):469-73. PubMed ID: 2570852.
    Abstract:
    Rabbit lung and heart show clorgyline-resistant benzylamine oxidase activity which is sensitive to semicarbazide (SSAO) and alpha-amino-guanidine. This SSAO activity is inhibited by pyridoxamine with an IC50 of 6.3 x -6 M for lung and of 1.1 x 10(-5) M for heart, the inhibition being non-competitive and only partially reversed by dialysis at 4 degrees C. Semicarbazide, alpha-aminoguanidine and pyridoxamine show a similar time-dependent type of inhibition of rabbit lung and heart SSAO.
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