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  • Title: Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams--conversion of ikarugamycin to butremycin.
    Author: Greunke C, Antosch J, Gulder TA.
    Journal: Chem Commun (Camb); 2015 Mar 28; 51(25):5334-6. PubMed ID: 25711294.
    Abstract:
    Polycyclic tetramate macrolactams (PTMs) are a structurally, biomedically and biosynthetically intriguing class of bacterial metabolites. By combining parts of the machineries of different PTM biosynthetic pathways, we demonstrate for the first time the substrate promiscuity of a class of PTM tailoring enzymes, thereby facilitating the (bio)synthesis of butremycin.
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