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  • Title: The effect of azelastine and some other antiasthmatic and antiallergic drugs on calmodulin and protein kinase C.
    Author: Middleton E, Ferriola P, Drzewiecki G, Sofia RD.
    Journal: Agents Actions; 1989 Aug; 28(1-2):9-15. PubMed ID: 2571246.
    Abstract:
    The antiallergic and antiasthmatic drug, azelastine, interacts strongly with calmodulin (but not bovine serum albumin) as determined by an indirect assay; it also moderately inhibited the Ca2+-calmodulin-dependent enzyme bovine brain phosphodiesterase. Ketotifen was less active than azelastine in both assays of calmodulin reactivity and both drugs were less active than the recognized calmodulin inhibitor, W-7. Neither azelastine nor ketotifen had any inhibitory effect on the Ca2+- and phospholipid-dependent protein kinase C. A number of other commonly employed antiallergic and antiasthmatic drugs were essentially inactive in the calmodulin assays and had no or marginal inhibitory effect on protein kinase C.
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