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  • Title: Postnatal effects of maternal nicotine exposure on the striatal dopaminergic system in rats.
    Author: Fung YK.
    Journal: J Pharm Pharmacol; 1989 Aug; 41(8):576-8. PubMed ID: 2571708.
    Abstract:
    The biochemical effects of continuous prenatal exposure to nicotine (1.5 mg kg-1 day-1) have been examined in 14 day old male and female rat pups. The ability of striatal tissue slices from the nicotine-exposed pups to synthesize [3H]dopamine from [3H]tyrosine was enhanced. However, the ability of (+)-amphetamine to stimulate formation and release of [3H]dopamine from [3H]tyrosine was not affected. Furthermore, prenatal exposure to nicotine increased the rate of striatal dopamine turnover in the male, but not the female nicotine-exposed pups.
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