These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Association between TLR4 A299G polymorphism and pneumonia risk: a meta-analysis.
    Author: Cai X, Fu Y, Chen Q.
    Journal: Med Sci Monit; 2015 Feb 27; 21():625-9. PubMed ID: 25720378.
    Abstract:
    BACKGROUND: Several genetic studies have evaluated the association between Toll-like receptor 4 (TLR4) A299G polymorphism and the risk of pneumonia. However, the results were not consistent. We thus did this meta-analysis. MATERIAL AND METHODS: Relevant studies were systematically searched by using the NCBI, Medline, Web of Science, and Embase databases. Data were extracted independently by 2 investigators. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated. RESULTS: Eight case-control studies with 658 patients and 1862 controls were included in this meta-analysis. TLR4 A299G polymorphism was significantly associated with pneumonia risk (OR=1.74; 95% CI 1.19-2.53; P=0.004). The result was significant in adults. In addition, TLR4 A299G polymorphism was also associated with community-acquired pneumonia (CAP) risk. Results from cumulative meta-analysis and sensitivity analysis suggested that the results are reliable and robust. CONCLUSIONS: The results of this meta-analysis suggest that susceptibility to pneumonia was associated with TLR4 A299G polymorphism.
    [Abstract] [Full Text] [Related] [New Search]