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  • Title: Effect of beta-adrenoceptor agents on the blood flow in carotid arteries in normal volunteers.
    Author: Fitzgerald DE, Harry JD.
    Journal: Br J Clin Pharmacol; 1989; 28 Suppl 1(Suppl 1):73S-74S. PubMed ID: 2572260.
    Abstract:
    The effects on carotid artery blood flow of atenolol (a selective beta 1-adrenoceptor antagonist) and xamoterol (a beta 1-adrenoceptor partial agonist with 43% agonist activity) were measured using a Doppler technique in eight healthy volunteers. Atenolol produced a decrease in blood pressure and blood velocity flow, and tended to reduce volume flow. In contrast, there were no changes with xamoterol or placebo. Beta 1-adrenoceptor blockade may reduce cerebral blood flow but the partial agonist xamoterol does not appear to reduce carotid blood flow.
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