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  • Title: Studies on antiallergy agents. III. Synthesis of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids and related compounds.
    Author: Ozeki K, Ichikawa T, Takehara H, Tanimura K, Sato M, Yaginuma H.
    Journal: Chem Pharm Bull (Tokyo); 1989 Jul; 37(7):1780-7. PubMed ID: 2572333.
    Abstract:
    A series of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids with various substituents was synthesized and evaluated in the rat passive cutaneous anaphylaxis test for antiallergic activity. High activity by intraperitoneal and oral administrations was observed for the 3-trifluoromethyl and 2-alkoxyanilino derivatives (64, 79, 81, 82 and 85). Structure-activity relationships are discussed.
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