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  • Title: Muscarinic receptors modulating acetylcholine release from insect synaptosomes.
    Author: Knipper M, Breer H.
    Journal: Comp Biochem Physiol C Comp Pharmacol Toxicol; 1989; 93(2):287-92. PubMed ID: 2572383.
    Abstract:
    1. Cholinergic synapses in the central nervous system of insects contain inhibitory muscarinic receptors whose stimulation by agonists leads to a diminished output of acetylcholine; antagonists, like atropine, facilitate acetylcholine release. 2. The receptors involved appear to be of the M2-subtype. Upon activation of presynaptic receptors a significant reduction of the intrasynaptosomal cyclic AMP level as well as a significantly increased membrane potential was observed. 3. The observed membrane hyperpolarization is apparently not a consequence of a lower cyclic AMP level, thus both effects may offer alternative or synergistical mechanisms for modulating transmitter release.
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