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  • Title: Clinical melperone treatment blocks D2-dopamine receptors in the human brain as determined by PET.
    Author: Wiesel FA, Farde L, Halldin C.
    Journal: Acta Psychiatr Scand Suppl; 1989; 352():30-4. PubMed ID: 2573239.
    Abstract:
    Positron emission tomography and 11-C-labelled raclopride was used to determine central D2-dopamine receptor occupancy in three melperone treated patients. Treatment with melperone in daily doses of 250 and 300 mg for 3 to 6 weeks, resulted in a receptor occupancy above 70%. Thus, clinical doses of melperone as we previously demonstrated for several classical neuroleptics cause a substantial D2-dopamine receptor blockade in the human brain in vivo.
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