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  • Title: Sensitivity to both vecuronium and neostigmine in a sero-negative myasthenic patient.
    Author: Kim JM, Mangold J.
    Journal: Br J Anaesth; 1989 Oct; 63(4):497-500. PubMed ID: 2573388.
    Abstract:
    We describe a sero-negative ocular myasthenic patient who showed exaggerated responses to both vecuronium and neostigmine. These hypersensitive responses were not anticipated because preoperative clinical and laboratory evaluations suggested a negligible impairment of somatic muscles by myasthenic processes. This case report re-emphasizes that, if neuromuscular blocking agents and their antagonists are administered to myasthenic patients, regardless of the degree of impairment, the dose should be titrated carefully with the aid of a neuromuscular transmission monitor.
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