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  • Title: [Synaptosomal factors, regulating the activity of Na,K-ATPase and its sensitivity to neurotransmitters].
    Author: Tsakadze LG, Kometiani ZP.
    Journal: Biokhimiia; 1989 Aug; 54(8):1274-9. PubMed ID: 2573394.
    Abstract:
    The factors regulating the activity of synaptosomal Na,K-ATPase have been found in nerve endings cytosol. One of these (Mr 10,000) essentially inhibits, whereas the other one (Mr 60,000) in the presence of norepinephrine, 5-hydroxytryptamine and dopamine activates the Na,K-ATPase of synaptosomes. Regardless of their direct action on Na,K-ATPase, the effect of the activating factor increases in the presence of neurotransmitters. In cell ksap obtained by microsome precipitation the activating factor is absent.
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