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  • Title: Ratiometric iridium(III) complex-based phosphorescent chemodosimeter for Hg(2+) applicable in time-resolved luminescence assay and live cell imaging.
    Author: Ru J, Chen X, Guan L, Tang X, Wang C, Meng Y, Zhang G, Liu W.
    Journal: Anal Chem; 2015 Mar 17; 87(6):3255-62. PubMed ID: 25734951.
    Abstract:
    A novel iridium(III) complex-based probe Ir4-1 has been designed and synthesized conveniently by incorporating the chemodosimeter into phosphorescent luminophor, which displayed ratiometric luminescence change from yellowish-green to reddish-yellow only toward Hg(2+) ions in aqueous media via desulfurization and intramolecular cyclization with a broad pH range of 5-10. The phosphorescent chemodosimeter could eliminate effectively the signal interference from the short-lived fluorescent background, and the signal-to-noise ratio of the detection was improved distinctly by using time-resolved photoluminescence technique. Furthermore, the mechanism of phosphoresce change of the chemodosimeter was analyzed in detail by time-dependent density functional theory (TD-DFT) calculations, and the probe with long-wavelength emission could be applied to label cells and monitor intracellular Hg(2+) effectively by luminescence ratio imaging.
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