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  • Title: The value of the urinary protein:creatinine ratio for the detection of significant proteinuria in women with suspected preeclampsia.
    Author: Bhide A, Rana R, Dhavilkar M, Amodio-Hernandez M, Deshpande D, Caric V.
    Journal: Acta Obstet Gynecol Scand; 2015 May; 94(5):542-6. PubMed ID: 25737188.
    Abstract:
    To explore the correlation between urinary protein:creatinine ratio and 24-h excretion of protein, we studied 149 women referred to a day assessment unit for investigations for suspected preeclampsia. Paired samples were obtained for measurement of urinary protein:creatinine ratio and 24-h protein excretion. Collection of a 24-h urine sample was validated by the daily creatinine excretion. The outcome measure was proteinuria of 300 mg/day or more. Inaccurate 24-h collection was observed in 17% of women. All women (n = 56) with a protein:creatinine ratio >60 mg/mM had significant proteinuria. No woman with protein:creatinine ratio <18 mg/mM (n = 20) had significant proteinuria. We recommend that a dual cut-off should be used for excluding and "ruling in" the diagnosis of significant proteinuria. A 24-h urine collection should be used only for urinary protein:creatinine ratio values between 18 and 60 mg/mM in the detection of significant proteinuria.
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