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  • Title: [The effect of prolonged antiorthostatic hypokinesia on the blood serum activity of enzymes involved in energy and plastic metabolism].
    Author: Popova IA, Vetrova EG, Drozdova TE.
    Journal: Kosm Biol Aviakosm Med; 1989; 23(4):51-5. PubMed ID: 2573751.
    Abstract:
    In the course of 370-day antiorthostatic (-5 degrees) hypokinesia in which 9 test subjects participated the following changes in serum enzymes associated with energy metabolism inhibition were recorded: decreases of creatine phosphokinase (CPK) at the expense of its MM-isoform, isocitrate and glutamate dehydrogenases as well as increases of alanine and aspartate aminotransferases, gamma-glutamyl transferase, and lactate dehydrogenase (LDH) at the expense of an increased portion of its aerobic H-isoforms. During the recovery period these parameters returned to the norm. The counter-measures used (drugs combined with exercise) exerted a beneficial effect only in relation to CPK, gamma-glutamyl transferase and aspartate aminotransferase.
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