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  • Title: D-aspartate potentiates the effects of both L-aspartate and L-glutamate on carp horizontal cells.
    Author: Mangel SC, Ariel M, Dowling JE.
    Journal: Neuroscience; 1989; 32(1):19-26. PubMed ID: 2573859.
    Abstract:
    L-Aspartate, L-glutamate and D-aspartate, alone or in combination, were applied by superfusion or by atomization to the isolated carp retina while recording from cone horizontal cells. Each of these agents when applied alone depolarized horizontal cells and reduced the size of their light responses, an action which mimics the effect of the endogenous photoreceptor transmitter. Application of D-aspartate in conjunction with either of the L-amino acids potentiated the effects the L-amino acids so that the threshold concentration was reduced by about five-fold, compared to when the L-amino acids were applied alone. The potentiating effect of D-aspartate occurred with all types of cone horizontal cells--both L- and C-types. Furthermore, the potentiating effect of D-aspartate occurred not only in the dark but also in the presence of bright light background or Co2+ ions, conditions during which the release of photoreceptor transmitter is reduced or blocked. D-Aspartate also potentiated the depolarizing effects of the acidic amino acid cysteine sulfinate. The potentiating effect of D-aspartate can be attributed to its action as an amino acid uptake blocker in the outer retina. Thus, these findings, in themselves, cannot eliminate L-aspartate, L-glutamate or cysteine sulfinate as candidates for the carp cone transmitter. However, other evidence, previously reported, strongly suggests that L-glutamate and not L-aspartate is the cone transmitter.
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