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  • Title: Clinicoradiologic response of neurologic tuberculous mass lesions in children treated with thalidomide.
    Author: van Toorn R, du Plessis AM, Schaaf HS, Buys H, Hewlett RH, Schoeman JF.
    Journal: Pediatr Infect Dis J; 2015 Feb; 34(2):214-8. PubMed ID: 25741973.
    Abstract:
    Neurologic tuberculous pseudoabscesses that clinically progress despite conventional antituberculosis therapy may be responsive to adjuvant thalidomide, a potent tumor necrosis factor-α inhibitor. In this study, the addition of thalidomide provided substantial clinical benefit in the majority of patients, and magnetic resonance imaging evolution of lesions from early-stage "T2 bright" with edema to "T2 black" represented a marker of cure.
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